2. Academic Validation
  3. Synthesis, anti-Candida activity, and cytotoxicity of new (4-(4-iodophenyl)thiazol-2-yl)hydrazine derivatives

Synthesis, anti-Candida activity, and cytotoxicity of new (4-(4-iodophenyl)thiazol-2-yl)hydrazine derivatives

  • Eur J Med Chem. 2012 Jul:53:246-53. doi: 10.1016/j.ejmech.2012.04.006.
Daniela Secci 1,  Bruna Bizzarri,  Adriana Bolasco,  Simone Carradori,  Melissa D'Ascenzio,  Daniela Rivanera,  Emanuela Mari,  Lucia Polletta,  Alessandra Zicari
Affiliations

Affiliation

  • 1 Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Ple A Moro 5, 00185 Rome, Italy.
PMID: 22560629 DOI: 10.1016/j.ejmech.2012.04.006
Abstract

Novel (4-(4-iodophenyl)-thiazol-2-yl)hydrazine derivatives were assayed for their in vitro anti-Candida activity, compared to topical and systemic Antifungal drugs, against twenty-seven clinical isolates. The presence of aliphatic chains or specific heteroaromatic rings on hydrazone moiety at position C2 and a 4-iodophenyl at C4 of the thiazole ring gave a promising inhibitory activity especially against Candida albicans and Candida krusei. The most active compounds have been also evaluated for their cytotoxicity and in association with clotrimazole for anti-Candida activity.

Figures