2. Academic Validation
  3. Glyoxal formation and its role in endogenous oxalate synthesis

Glyoxal formation and its role in endogenous oxalate synthesis

  • Adv Urol. 2012:2012:819202. doi: 10.1155/2012/819202.
Jessica N Lange 1,  Kyle D Wood,  John Knight,  Dean G Assimos,  Ross P Holmes
Affiliations

Affiliation

  • 1 Department of Urology, Wake Forest University Medical Center, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
PMID: 22567004 DOI: 10.1155/2012/819202
Abstract

Calcium oxalate kidney stones are a common condition affecting many people in the United States. The concentration of oxalate in urine is a major risk factor for stone formation. There is evidence that glyoxal metabolism may be an important contributor to urinary oxalate excretion. Endogenous sources of glyoxal include the catabolism of carbohydrates, proteins, and fats. Here, we review all the known sources of glyoxal as well as its relationship to oxalate synthesis and crystal formation.

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