2. Academic Validation
  3. Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry

Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry

  • Eur J Med Chem. 2012 Jul:53:356-63. doi: 10.1016/j.ejmech.2012.04.026.
Yikai Zhang 1,  Zhiliang Lv,  Hanyu Zhong,  Dongping Geng,  Mingfeng Zhang,  Tao Zhang,  Yongmei Li,  Ke Li
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, No 325, Guohe Road, Shanghai 200433, China.
PMID: 22579780 DOI: 10.1016/j.ejmech.2012.04.026
Abstract

Based on the advantages of Natural Products in new anti-cancer drug development, we synthesized a series of novel benzopyran-4-one derivatives and evaluated their in vitro anti-cancer activities. The bioassays showed that the majority of the resultant compounds exerted anti-tumor effect against six human Cancer cell lines to various extents, which supported the rationale of the design. Compound 5s exhibited highest potency of all the synthesized compounds.

Figures