2. Academic Validation
  3. Halogenated spirotetronates from Actinoallomurus

Halogenated spirotetronates from Actinoallomurus

  • J Nat Prod. 2012 Jun 22;75(6):1044-50. doi: 10.1021/np300003n.
Carlo Mazzetti 1,  Mirko Ornaghi,  Eleonora Gaspari,  Silvia Parapini,  Sonia Maffioli,  Margherita Sosio,  Stefano Donadio
Affiliations

Affiliation

  • 1 NAICONS, Via G. Fantoli 16/15, 20138, Milan, Italy. dr.carlo.mazzetti@tiscali.it
PMID: 22616554 DOI: 10.1021/np300003n
Abstract

Two new members of the spirotetronate class, nai414-A and nai414-B, were discovered and isolated from an Actinoallomurus sp. Their structures were established by 1D and 2D NMR, UV, and MS analyses and by chemical degradation. They showed antimicrobial and antitumor activity against Gram-positive bacteria and against human microvascular endothelial cells, respectively. Substituting bromide for chloride ions in the growth medium afforded mono- and dibrominated derivatives.

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