2. Academic Validation
  3. Synthesis and selective cytotoxic activity of novel hybrid chalcones against prostate cancer cells

Synthesis and selective cytotoxic activity of novel hybrid chalcones against prostate cancer cells

  • Bioorg Med Chem Lett. 2012 Jul 1;22(13):4314-7. doi: 10.1016/j.bmcl.2012.05.016.
M Nagaraju 1,  E Gnana Deepthi,  C Ashwini,  M V P S Vishnuvardhan,  V Lakshma Nayak,  Rajesh Chandra,  S Ramakrishna,  B B Gawali
Affiliations

Affiliation

  • 1 Organic Chemistry Division-II, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 607, India.
PMID: 22668451 DOI: 10.1016/j.bmcl.2012.05.016
Abstract

A new class of hybrid Chalcones (17a-l &18a-l) was synthesized by Claisen-Schmidt condensation. All compounds were characterized by (1)H NMR, IR and mass spectral analysis and tested for their cytotoxic activity against PC-3 (prostate Cancer), HT-29 (colon Cancer), B-16 (mouse macrophages) and NCI-H460 (lung Cancer) cell lines. Three compounds 18i, 18j and 18l (IC(50)=8.4, 7.9 & 5.9 μM) showed significant activity against PC-3 cell line.

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