2. Academic Validation
  3. Anthranilic acid-based diamides derivatives incorporating aryl-isoxazoline pharmacophore as potential anticancer agents: design, synthesis and biological evaluation

Anthranilic acid-based diamides derivatives incorporating aryl-isoxazoline pharmacophore as potential anticancer agents: design, synthesis and biological evaluation

  • Eur J Med Chem. 2012 Aug:54:549-56. doi: 10.1016/j.ejmech.2012.06.001.
Liqiao Shi 1,  Rui Hu,  Yanhong Wei,  Ying Liang,  Ziwen Yang,  Shaoyong Ke
Affiliations

Affiliation

  • 1 National Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, No. 8, Nanhu Avenue, Wuhan 430064, PR China.
PMID: 22727445 DOI: 10.1016/j.ejmech.2012.06.001
Abstract

A series of novel anthranilic diamides derivatives containing aryl-isoxazoline moiety were designed and synthesized as a part of our ongoing search for potential Anticancer agents. Their structures were confirmed by (1)H NMR, (13)C NMR and ESI-MS analyses. The preliminary assays showed that some of the compounds displayed moderate to good antitumor activities against human lung Cancer (NCI-H460), hepatocellular liver carcinoma (HepG2), gastric Cancer (SGC-7901 and BGC-823) and breast epithelial adenocarcinoma (MCF-7) cell lines at μM level, which might be developed as novel lead scaffold for potential Anticancer agents.

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