2. Academic Validation
  3. New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms

New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms

  • Bioorg Med Chem. 2012 Aug 15;20(16):4995-5000. doi: 10.1016/j.bmc.2012.06.027.
Paula F Carneiro 1,  Samara B do Nascimento,  Antonio V Pinto,  Maria do Carmo F R Pinto,  Guilherme C Lechuga,  Dilvani O Santos,  Helvécio M dos Santos Júnior,  Jackson A L C Resende,  Saulo C Bourguignon,  Vitor F Ferreira
Affiliations

Affiliation

  • 1 Universidade Federal do Rio de Janeiro, Núcleo de Pesquisas de Produtos Naturais, 21944-970 Cidade Universitária, RJ, Brazil.
PMID: 22795899 DOI: 10.1016/j.bmc.2012.06.027
Abstract

New oxirane derivatives were synthesized using six naphthoquinones as the starting Materials. Our biological results showed that these oxiranes acted as trypanocidal agents against Trypanosoma cruzi with minimal cytotoxicity in the VERO cell line compared to naphthoquinones. In particular, oxirane derivative 14 showed low cytotoxicity in a mammalian cell line and exhibited better activity against epimastigote forms of T.cruzi than the current drug used to treat Chagas disease, benznidazole.

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