2. Academic Validation
  3. Alkaloids from Melodinus yunnanensis

Alkaloids from Melodinus yunnanensis

  • Phytochemistry. 2012 Nov;83:116-24. doi: 10.1016/j.phytochem.2012.06.013.
Xiang-Hai Cai 1,  Yan Li,  Ya-Ping Liu,  Xiao-Ning Li,  Mei-Fen Bao,  Xiao-Dong Luo
Affiliations

Affiliation

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China. xhcai@mail.kib.ac.cn
PMID: 22818523 DOI: 10.1016/j.phytochem.2012.06.013
Abstract

Ten monoterpenoid Indole Alkaloids, namely meloyine, 19S-methoxytubotaiwine N₄-oxide, 16,19-epoxy-Δ¹⁴-vincanol, 14β-hydroxymeloyunine, meloyunine, Δ¹⁴-vincamenine N₄-oxide, 16β,21β-epoxy-vincadine, 14β,15β-20S-quebrachamine, 3-oxo-voaphylline, 2α,7α-dihydroxy-dihydrovoaphylline, and 32 known Alkaloids were isolated from leaves and twigs of Melodinus yunnanensis. Their structures were elucidated based on 1- and 2-D NMR, FTIR, UV, and MS spectroscopic data. Meloyine I showed weak cytotoxic activity against four human Cancer cell lines: MCF-7 breast Cancer, SMMC-7721 hepatocellular carcinoma, HL-60 myeloid leukemia, and A-549 lung Cancer.

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