2. Academic Validation
  3. Synthesis and biological evaluation of a new vitamin D2 analogue

Synthesis and biological evaluation of a new vitamin D2 analogue

  • Bioorg Med Chem Lett. 2012 Oct 1;22(19):6276-9. doi: 10.1016/j.bmcl.2012.07.095.
Zoila Gándara 1,  Manuel Pérez,  Débora G Salomón,  María J Ferronato,  María E Fermento,  Alejandro C Curino,  María M Facchinetti,  Generosa Gómez,  Yagamare Fall
Affiliations

Affiliation

  • 1 Departamento de Química Orgánica, Facultad de Química, Universidad de Vigo, 36200 Vigo, Spain.
PMID: 22926068 DOI: 10.1016/j.bmcl.2012.07.095
Abstract

A new vitamin D(2) analogue was synthesized using the Julia-Kocienski olefination. It has antiproliferative effects on cell lines from squamous cell carcinomas of colon and head and neck, but is also as hypercalcaemic as calcitriol in vivo.

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