2. Academic Validation
  3. Biological activity evaluation and structure-activity relationships analysis of ferulic acid and caffeic acid derivatives for anticancer

Biological activity evaluation and structure-activity relationships analysis of ferulic acid and caffeic acid derivatives for anticancer

  • Bioorg Med Chem Lett. 2012 Oct 1;22(19):6085-8. doi: 10.1016/j.bmcl.2012.08.038.
Weixia Li 1,  Nianguang Li,  Yuping Tang,  Baoquan Li,  Li Liu,  Xu Zhang,  Haian Fu,  Jin-Ao Duan
Affiliations

Affiliation

  • 1 Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210046, China.
PMID: 22954735 DOI: 10.1016/j.bmcl.2012.08.038
Abstract

The Anticancer activities of alkyl esters and NO-donors of ferulic acid (FA) and caffeic acid (CA) were assessed by a high-throughout screening (HTS) method, and the structure-activity relationships were described. CA alkyl esters had better Anticancer activities than FA alkyl esters with the same alkyl substituent. Mono-nitrates and phenylfuroxan nitrates were more potent than the dual nitrates. Phenylsulfonylfuroxan nitrates of FA, especially compounds 8b-8d, exhibited more potent activities in Anticancer.

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