1. Academic Validation
  2. Bi-, tri-, and polycyclic acylphloroglucinols from Hypericum empetrifolium

Bi-, tri-, and polycyclic acylphloroglucinols from Hypericum empetrifolium

  • J Nat Prod. 2012 Oct 26;75(10):1697-705. doi: 10.1021/np300237n.
Sebastian Schmidt 1 Guido Jürgenliemk Thomas J Schmidt Helen Skaltsa Jörg Heilmann
Affiliations

Affiliation

  • 1 Pharmaceutical Biology, Universität Regensburg , Universitätsstraße 31, D-93053 Regensburg, Germany.
Abstract

The ¹H NMR-guided fractionation of a petroleum ether extract of Hypericum empetrifolium led to the isolation of four new bicyclic (1-4), four known bicyclic (5-8), three new tricyclic (9-11), and three new polycyclic acylphloroglucinols (12/13 and 14) possessing a monoterpenoid citran moiety. Compounds 12/13 were isolated as a mixture of two inseparable structural isomers. The compounds showed in vitro antiproliferative activity against human microvascular endothelial cells (HMEC-1) with IC₅₀ values in the range 9.2 ± 2.0 to 29.6 ± 3.5 μM.

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