2. Academic Validation
  3. Viridin analogs derived from steroidal building blocks

Viridin analogs derived from steroidal building blocks

  • Bioorg Med Chem Lett. 2012 Nov 15;22(22):6919-22. doi: 10.1016/j.bmcl.2012.09.015.
Kishore Viswanathan 1,  Sophia N Ononye,  Harold D Cooper,  M Kyle Hadden,  Amy C Anderson,  Dennis L Wright
Affiliations

Affiliation

  • 1 Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, United States.
PMID: 23040731 DOI: 10.1016/j.bmcl.2012.09.015
Abstract

Naturally occurring furanosteroids such as viridin and wortmannin have long been known as potent inhibitors of the lipid kinase PI-3K. We have been interested in directly accessing analogs of these complex Natural Products from abundant steroid feedstock Materials. In this communication, we describe the synthesis of viridin/wortmannin hybrid molecules from readily available building blocks that function as PI-3K inhibitors and maintain their electrophilic properties. The compounds also show anti-proliferative effects against a breast Cancer line.

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