2. Academic Validation
  3. Synthesis of pyrazole peptidomimetics and their inhibition against A549 lung cancer cells

Synthesis of pyrazole peptidomimetics and their inhibition against A549 lung cancer cells

  • Bioorg Med Chem Lett. 2012 Nov 15;22(22):6882-7. doi: 10.1016/j.bmcl.2012.09.032.
Ying-Rui Liu 1,  Ji-Zhuang Luo,  Pan-Pan Duan,  Jing Shao,  Bao-Xiang Zhao,  Jun-Ying Miao
Affiliations

Affiliation

  • 1 Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, PR China.
PMID: 23044370 DOI: 10.1016/j.bmcl.2012.09.032
Abstract

A series of novel pyrazole peptidomimetics was synthesized from 3-aryl-1-arylmethyl-1H-pyrazole-5-carboxylic acid and amino acid ester. Structures of the compounds were characterized by means of IR, (1)H NMR and mass spectroscopy. Compounds 5e and 5k suppress effectively the growth of A549 lung Cancer cells. Preliminary research on the mechanism of action showed that the inhibition might perform through combination of Apoptosis, Autophagy and cell cycle arrest.

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