1. Academic Validation
  2. Urease inhibitory isoflavonoids from different parts of Calopogonium mucunoides (Fabaceae)

Urease inhibitory isoflavonoids from different parts of Calopogonium mucunoides (Fabaceae)

  • J Enzyme Inhib Med Chem. 2013 Dec;28(6):1156-61. doi: 10.3109/14756366.2012.719025.
Brigitte Ndemangou 1 Valerie Tedjon Sielinou Juliette Catherine Vardamides Muhammad Shaiq Ali Mehreen Lateef Lubna Iqbal Nigaht Afza Augustin Ephrem Nkengfack
Affiliations

Affiliation

  • 1 Department of Organic Chemistry, Faculty of Science, University of Yaounde I , Yaoundé , Cameroon.
Abstract

The dichloromethane-methanol (1:1) soluble part of Calopogonium mucunoides (Fabaceae) resulted in the isolation of 10 Isoflavones (4'-O-methylalpinumisoflavone, 4'-O-methylderrone, alpinumisoflavone, daidzeine, Calopogonium isoflavone A, atalantoflavone, 2',4',5',7-tetramethoxyisoflavone, 7-O-methylcuneantin, cabreuvin and 7-O-methylpseudobaptigenin) and a rotenoid (6a,12a-dehydroxydegueline). Among these, daidzeine, 7-O-methylcuneantin, atalantoflavone and 6a, 12a-dehydroxydegueline have been isolated for the first time from C. mucunoides while remaining are already reported from this source. Structures of all the isolated constituents were elucidated with the aid of NMR spectroscopic and mass spectrometric techniques. Among all the isolated constituents, nine were evaluated for their urease inhibitory potential. However, six were found potent. These include 4'-O-methylderrone, daidzeine, atalantoflavone, 2',4',5',7-tetramethoxyisoflavone, 7-O-methylcuneantin and 6a, 12a-dehydroxydegueline.

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