2. Academic Validation
  3. Antiproliferative activity of salinomycin and its derivatives

Antiproliferative activity of salinomycin and its derivatives

  • Bioorg Med Chem Lett. 2012 Dec 1;22(23):7146-50. doi: 10.1016/j.bmcl.2012.09.068.
Adam Huczyński 1,  Jan Janczak,  Michał Antoszczak,  Joanna Wietrzyk,  Ewa Maj,  Bogumil Brzezinski
Affiliations

Affiliation

  • 1 Faculty of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60-780 Poznan, Poland. adhucz@amu.edu.pl
PMID: 23079523 DOI: 10.1016/j.bmcl.2012.09.068
Abstract

Antiproliferative activity of seven amides and one benzotriazole ester derivative of salinomycin, a polyether ionophore Antibiotic, with recently reported Antibacterial activity, are herein described. Salinomycin and the majority of derivatives exhibit potent antiproliferative activity against the drug-resistant Cancer cell lines. Moreover almost all derivatives show stronger activity against LoVo/DX cell line than that of unmodified salinomycin.

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