2. Academic Validation
  3. Cytotoxic indole diketopiperazines from the deep sea-derived fungus Acrostalagmus luteoalbus SCSIO F457

Cytotoxic indole diketopiperazines from the deep sea-derived fungus Acrostalagmus luteoalbus SCSIO F457

  • Bioorg Med Chem Lett. 2012 Dec 1;22(23):7265-7. doi: 10.1016/j.bmcl.2012.08.115.
Fa-Zuo Wang 1,  Zhi Huang,  Xue-Feng Shi,  Yu-Chan Chen,  Wei-Min Zhang,  Xin-Peng Tian,  Jie Li,  Si Zhang
Affiliations

Affiliation

  • 1 CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.
PMID: 23079524 DOI: 10.1016/j.bmcl.2012.08.115
Abstract

Two new indole diketopiperazines, namely luteoalbusins A-B (1-2), along with eight known ones (3-10), were isolated from the fungus Acrostalagmus luteoalbus SCSIO F457 originated from deep-sea sediment. Their structures were determined by 1D/2D NMR, MS, and CD data analyses. Each of these compounds was evaluated for their cytotoxic activities against SF-268, MCF-7, NCI-H460, and HepG-2 cell lines, and compounds 1-5 showed significant cytotoxicties against all four Cancer cell lines. Moreover, new compounds 1 and 2 had more potent cytotoxicity than the Other ones and cisplatin.

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