2. Academic Validation
  3. IL-4 in the brain: a cytokine to remember

IL-4 in the brain: a cytokine to remember

  • J Immunol. 2012 Nov 1;189(9):4213-9. doi: 10.4049/jimmunol.1202246.
Sachin P Gadani 1,  James C Cronk,  Geoffrey T Norris,  Jonathan Kipnis
Affiliations

Affiliation

  • 1 Department of Neuroscience and Graduate Program in Neuroscience, Center for Brain Immunology and Glia, University of Virginia, Charlottesville, VA 22908, USA.
PMID: 23087426 DOI: 10.4049/jimmunol.1202246
Abstract

IL-4 has been extensively studied in the context of its role in immunity. Accumulating evidence indicates, however, that it also plays a critical role in higher functions of the normal brain, such as memory and learning. In this review, we summarize current knowledge of the basic immunology of IL-4, describe how and where this cytokine appears to operate in normal brain function, and propose a hypothesis concerning its potential role in neurological pathologies.

Figures
Products