2. Academic Validation
  3. Strynuxlines A and B, alkaloids with an unprecedented carbon skeleton from Strychnos nux-vomica

Strynuxlines A and B, alkaloids with an unprecedented carbon skeleton from Strychnos nux-vomica

  • J Nat Prod. 2012 Nov 26;75(11):1987-90. doi: 10.1021/np300339r.
Yanhui Fu 1,  Yu Zhang,  Hongping He,  Li Hou,  Yingtong Di,  Shunlin Li,  Xiaodong Luo,  Xiaojiang Hao
Affiliations

Affiliation

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, Yunnan, People's Republic of China.
PMID: 23088673 DOI: 10.1021/np300339r
Abstract

The investigation of the seeds of Strychnos nux-vomica led to the isolation of two novel Indole Alkaloids, strynuxlines A (1) and B (2), with an unprecedented 6/5/9/6/7/6 hexacyclic ring system. Their structures and absolute configurations were elucidated on the basis of their MS, NMR, and ECD data. A plausible biosynthesis pathway of 1 and 2 is also proposed.

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