2. Academic Validation
  3. Fluostatins I-K from the South China Sea-derived micromonospora rosaria SCSIO N160

Fluostatins I-K from the South China Sea-derived micromonospora rosaria SCSIO N160

  • J Nat Prod. 2012 Nov 26;75(11):1937-43. doi: 10.1021/np300505y.
Wenjun Zhang 1,  Zhong Liu,  Sumei Li,  Yongzhi Lu,  Yuchan Chen,  Haibo Zhang,  Guangtao Zhang,  Yiguang Zhu,  Gaiyun Zhang,  Weimin Zhang,  Jinsong Liu,  Changsheng Zhang
Affiliations

Affiliation

  • 1 CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences , 164 West Xingang Road, Guangzhou 510301, People's Republic of China.
PMID: 23136829 DOI: 10.1021/np300505y
Abstract

The strain SCSIO N160 was isolated from a South China Sea sediment sample and was characterized as a Micromonospora rosaria species on the basis of its 16S rRNA gene sequence. Three new fluostatins, I-K (1-3), were isolated from the culture of M. rosaria SCSIO N160, together with six known compounds, fluostatins C-F (4-7), rabelomycin (8), and phenanthroviridone (9). The structure of fluostatin D (5) was confirmed by an X-ray crystallographic study. The absolute configuration of 1 and 3 was assigned by electronic circular dichroism calculations. Compounds 8 and 9 exhibited good antimicrobial activities against Staphylococcus aureus ATCC 29213 with MIC values of 1.0 and 0.25 μg/mL, respectively. Compound 9 also exhibited significant in vitro cytotoxic activities toward SF-268 (IC50 0.09 μM) and MCF-7 (IC50 0.17 μM).

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