2. Academic Validation
  3. Non-benzimidazole containing inhibitors of respiratory syncytial virus

Non-benzimidazole containing inhibitors of respiratory syncytial virus

  • Bioorg Med Chem Lett. 2013 Feb 1;23(3):827-33. doi: 10.1016/j.bmcl.2012.11.062.
David C Pryde 1,  Thien-Duc Tran,  Iain Gardner,  Helen Bright,  Paul Stupple,  Sebastien Galan,  Liam Alsop,  Lesa Watson,  Donald S Middleton,  Satish Dayal,  Michelle Platts,  Edward J Murray,  Tanya Parkinson,  Robert Webster
Affiliations

Affiliation

  • 1 Worldwide Medicinal Chemistry, Pfizer Global R and D, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK. David.Pryde@pfizer.com
PMID: 23265891 DOI: 10.1016/j.bmcl.2012.11.062
Abstract

Several non-benzimidazole containing inhibitors of respiratory syncytial virus are described. Core template modification, analysis of Antiviral activity, physicochemistry and optimisation of properties led to the thiazole-imidazole 13, that showed a good potency and pharmacokinetic profile in the rat.

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