2. Academic Validation
  3. Pleurospiroketals A-E, perhydrobenzannulated 5,5-spiroketal sesquiterpenes from the edible mushroom Pleurotus cornucopiae

Pleurospiroketals A-E, perhydrobenzannulated 5,5-spiroketal sesquiterpenes from the edible mushroom Pleurotus cornucopiae

  • J Nat Prod. 2013 Jan 25;76(1):45-50. doi: 10.1021/np3006524.
Shao-juan Wang 1,  Li Bao,  Jun-jie Han,  Quan-xin Wang,  Xiao-li Yang,  Hua-an Wen,  Liang-dong Guo,  Shao-jie Li,  Feng Zhao,  Hong-wei Liu
Affiliations

Affiliation

  • 1 State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, No.9 Beiertiao, Zhongguancun, Haidian District, Beijing 100190, People's Republic of China.
PMID: 23294419 DOI: 10.1021/np3006524
Abstract

Five novel perhydrobenzannulated 5,5-spiroketal Sesquiterpenes, namely, pleurospiroketals A-E (1-5), were isolated from the culture of the edible mushroom Pleurotus cornucopiae. Pleurospiroketals D (4) and E (5) were obtained as an isomeric mixture with a ratio of 5:4. Their structures were established by NMR, X-ray single-crystal diffraction, and CD data analysis. Pleurospiroketals A-E (1-5) are sesquiterpenoids with a unique benzannulated 5,5-spiroketal skeleton. Compounds 1-3 showed inhibitory activity against nitric oxide production in lipopolysaccharide-activated macrophages with IC(50) values of 6.8, 12.6, and 20.8 μM, respectively.

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