2. Academic Validation
  3. Anti-inflammatory diterpenoids from Croton tonkinensis

Anti-inflammatory diterpenoids from Croton tonkinensis

  • J Nat Prod. 2013 Feb 22;76(2):230-6. doi: 10.1021/np300699f.
Ping-Chung Kuo 1,  Mei-Lin Yang,  Tsong-Long Hwang,  Yuan-Yu Lai,  Yue-Chiun Li,  Tran Dinh Thang,  Tian-Shung Wu
Affiliations

Affiliation

  • 1 Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan, Republic of China.
PMID: 23347584 DOI: 10.1021/np300699f
Abstract

Phytochemical investigation of the methanolic extract of Croton tonkinensis afforded two known kauranes (1, 2), eight new ent-kauranes (3-10), and 16 known ent-kaurane-type Diterpenoids (12-27). In addition, 30 known compounds were identified by comparison of their physical and spectroscopic data with reported data. Among the isolated compounds, ent-18-acetoxykaur-16-en-15-one (20) displayed the most significant inhibition of superoxide anion generation and Elastase release.

Figures