2. Academic Validation
  3. Lahorenoic acids A-C, ortho-dialkyl-substituted aromatic acids from the biocontrol strain Pseudomonas aurantiaca PB-St2

Lahorenoic acids A-C, ortho-dialkyl-substituted aromatic acids from the biocontrol strain Pseudomonas aurantiaca PB-St2

  • J Nat Prod. 2013 Feb 22;76(2):135-41. doi: 10.1021/np3005166.
Samina Mehnaz 1,  Rahman Shah Zaib Saleem,  Basit Yameen,  Isabelle Pianet,  Gregor Schnakenburg,  Halina Pietraszkiewicz,  Fred Valeriote,  Michaele Josten,  Hans-Georg Sahl,  Scott G Franzblau,  Harald Gross
Affiliations

Affiliation

  • 1 Department of Biological Sciences, Forman Christian College University, Lahore, Pakistan. saminamehnaz@fccollege.edu.pk
PMID: 23402329 DOI: 10.1021/np3005166
Abstract

Three new aromatic acids, named lahorenoic acids A (1), B (2), and C (3), have been isolated along with the known compounds phenazine-1-carboxylic acid (4), 2-hydroxyphenazine-1-carboxylic acid (5), 2-hydroxyphenazine (6), 2,8-dihydroxyphenazine (7), cyclo-Pro-Tyr (8), cyclo-Pro-Val (9), cyclo-Pro-Met (10), and WLIP (11) and characterized from the biocontrol strain Pseudomonas aurantiaca PB-St2. The structures of these compounds were deduced by 1D and 2D NMR spectroscopic and mass spectral data interpretation. Compounds 2, 4, and 7 showed moderate Antibacterial activity against mycobacteria and Other Gram-positive bacteria, while 4 was also found to exhibit cytotoxic and Antifungal properties.

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