Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3943-8. doi: 10.1073/pnas.1217271110.

Michael Chiorazzi ¹, Lixin Rui, Yandan Yang, Michele Ceribelli, Nima Tishbi, Carine W Maurer, Stella M Ranuncolo, Hong Zhao, Weihong Xu, Wing-Chung C Chan, Elaine S Jaffe, Randy D Gascoyne, Elias Campo, Andreas Rosenwald, German Ott, Jan Delabie, Lisa M Rimsza, Shai Shaham, Louis M Staudt

Affiliations

Affiliation

1 Laboratory of Developmental Genetics, The Rockefeller University, New York, NY 10065, USA.

PMID: 23431138 DOI: 10.1073/pnas.1217271110

Abstract

Cell death is a common metazoan cell fate, and its inactivation is central to human malignancy. In Caenorhabditis elegans, apoptotic cell death occurs via the activation of the Caspase CED-3 following binding of the EGL-1/BH3-only protein to the antiapoptotic CED-9/BCL2 protein. Here we report a major alternative mechanism for Caspase activation in vivo involving the F-box protein DRE-1. DRE-1 functions in parallel to EGL-1, requires CED-9 for activity, and binds to CED-9, suggesting that DRE-1 promotes Apoptosis by inactivating CED-9. FBXO10, a human protein related to DRE-1, binds BCL2 and promotes its degradation, thereby initiating cell death. Moreover, some human diffuse large B-cell lymphomas have inactivating mutations in FBXO10 or express FBXO10 at low levels. Our results suggest that DRE-1/FBXO10 is a conserved regulator of Apoptosis.

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