2. Academic Validation
  3. GOLPH3 regulates the migration and invasion of glioma cells though RhoA

GOLPH3 regulates the migration and invasion of glioma cells though RhoA

  • Biochem Biophys Res Commun. 2013 Apr 12;433(3):338-44. doi: 10.1016/j.bbrc.2013.03.003.
Xiuping Zhou 1,  Wenjian Zhan,  Wenbin Bian,  Lei Hua,  Qiong Shi,  Shao Xie,  Dongxu Yang,  Yanwei Li,  Xu Zhang,  Guanzheng Liu,  Rutong Yu
Affiliations

Affiliation

  • 1 Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, China. xpzhou@xzmc.edu.cn
PMID: 23500462 DOI: 10.1016/j.bbrc.2013.03.003
Abstract

Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development of several human cancers. However, the biological significance of GOLPH3 in glioma progression remains largely unknown. In this study, we report, for the first time, that downregulation of GOLPH3 led to clear reductions in glioma cell migration and invasion. In addition, downregulation of GOLPH3 inhibited the expression of the small GTPase RhoA as well as cytoskeletal reorganization, which are both required for glioma cell migration. Furthermore, we found that the observed reductions in glioma cell migration and RhoA level could be rescued by RhoA overexpression. Taken together, these results show that GOLPH3 contributes to the motility of glioma cells by regulating the expression of RhoA.

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