2. Academic Validation
  3. Cytotoxic, antitopoisomerase IIα, and anti-HIV-1 activities of triterpenoids isolated from leaves and twigs of Gardenia carinata

Cytotoxic, antitopoisomerase IIα, and anti-HIV-1 activities of triterpenoids isolated from leaves and twigs of Gardenia carinata

  • J Nat Prod. 2013 Apr 26;76(4):530-7. doi: 10.1021/np3006887.
Naowarat Kongkum 1,  Patoomratana Tuchinda,  Manat Pohmakotr,  Vichai Reutrakul,  Pawinee Piyachaturawat,  Surawat Jariyawat,  Kanoknetr Suksen,  Radeekorn Akkarawongsapat,  Jitra Kasisit,  Chanita Napaswad
Affiliations

Affiliation

  • 1 Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand.
PMID: 23550966 DOI: 10.1021/np3006887
Abstract

Eight new cycloartane triterpenoids (1-8), named carinatins A-H, and the known compounds secaubryolide (9) and dikamaliartane D (10) were isolated from the leaves and twigs of Gardenia carinata. Their structures were determined on the basis of spectroscopic methods. Cytotoxic, antitopoisomerase IIα, and anti-HIV-1 activities of compounds 1-7, 9, and 10 were investigated.

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