2. Academic Validation
  3. Sacchathridine A, a prostaglandin release inhibitor from Saccharothrix sp

Sacchathridine A, a prostaglandin release inhibitor from Saccharothrix sp

  • J Nat Prod. 2013 Apr 26;76(4):720-2. doi: 10.1021/np3006327.
Koichi Nakae 1,  Ikuko Kurata,  Fukiko Kojima,  Masayuki Igarashi,  Masaki Hatano,  Ryuichi Sawa,  Yumiko Kubota,  Hayamitsu Adachi,  Akio Nomoto
Affiliations

Affiliation

  • 1 Institute of Microbial Chemistry (BIKAKEN), Tokyo, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan. nakaek@bikaken.or.jp
PMID: 23581596 DOI: 10.1021/np3006327
Abstract

Sacchathridine A (1) was isolated from the fermentation broth of strain Saccharothrix sp. MI559-46F5. The structure was determined as a new naphthoquinone derivative with an acetylhydrazino moiety by a combination of NMR, MS spectral analyses, and chemical degradation. Compound 1 showed inhibitory activity of prostaglandin E2 release in a concentration-dependent manner from human synovial sarcoma cells, SW982, with an IC50 value of 1.0 μM, but had no effect on cell growth up to 30 μM.

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