2. Academic Validation
  3. Inhibition of VEGF expression in cancer cells and endothelial cell differentiation by synthetic stilbene derivatives

Inhibition of VEGF expression in cancer cells and endothelial cell differentiation by synthetic stilbene derivatives

  • Bioorg Med Chem. 2013 Jun 1;21(11):3010-5. doi: 10.1016/j.bmc.2013.03.072.
Rosa Martí-Centelles 1,  Rocío Cejudo-Marín,  Eva Falomir,  Juan Murga,  Miguel Carda,  J Alberto Marco
Affiliations

Affiliation

  • 1 Depart. de Q. Inorgánica y Orgánica, Univ. Jaume I, E-12071 Castellón, Spain.
PMID: 23623255 DOI: 10.1016/j.bmc.2013.03.072
Abstract

We here report the synthesis of several stilbene derivatives. They show a measurable inhibitory effect on angiogenesis, some of them to a higher degree than resveratrol. Test methods included cell proliferation and tube formation assays using bovine aorta endothelial cells. In addition, it has been confirmed through the Reverse Transcriptase/polymerase chain reaction experiment that these stilbene derivatives downregulate the expression of the gene related to the production of the angiogenesis factor VEGF in Cancer cells.

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