2. Academic Validation
  3. A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity

A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity

  • Bioorg Med Chem. 2013 Jul 1;21(13):3695-701. doi: 10.1016/j.bmc.2013.04.031.
Claudio Battilocchio 1,  Giovanna Poce,  Salvatore Alfonso,  Giulio Cesare Porretta,  Sara Consalvi,  Lidia Sautebin,  Simona Pace,  Antonietta Rossi,  Carla Ghelardini,  Lorenzo Di Cesare Mannelli,  Silvia Schenone,  Antonio Giordani,  Luigia Di Francesco,  Paola Patrignani,  Mariangela Biava
Affiliations

Affiliation

  • 1 Dipartimento di Studi di Chimica e Tecnologie del Farmaco, Università Sapienza, Piazzale Aldo Moro 5, I-00185 Roma, Italy.
PMID: 23680444 DOI: 10.1016/j.bmc.2013.04.031
Abstract

We report the synthesis and bio-pharmacological evaluation of a class of pyrrole derivatives featuring a small appendage fragment (carbaldehyde, oxime, nitrile) on the central core. Compound 1c proved to be extremely effective in vivo, showing an interesting anti-nociceptic profile that is comparable to reference compounds already marketed, hence representing a great stimulus for a further improvement of this class of molecules.

Figures