2. Academic Validation
  3. Synthesis of kojic acid derivatives as secondary binding site probes of D-amino acid oxidase

Synthesis of kojic acid derivatives as secondary binding site probes of D-amino acid oxidase

  • Bioorg Med Chem Lett. 2013 Jul 1;23(13):3910-3. doi: 10.1016/j.bmcl.2013.04.062.
Mithun Raje 1,  Niyada Hin,  Bridget Duvall,  Dana V Ferraris,  James F Berry,  Ajit G Thomas,  Jesse Alt,  Camilo Rojas,  Barbara S Slusher,  Takashi Tsukamoto
Affiliations

Affiliation

  • 1 Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA.
PMID: 23683589 DOI: 10.1016/j.bmcl.2013.04.062
Abstract

A series of kojic acid (5-hydroxy-2-hydroxymethyl-4H-pyran-4-one) derivatives were synthesized and tested for their ability to inhibit D-amino acid oxidase (DAAO). Various substituents were incorporated into kojic acid at its 2-hydroxymethyl group. These analogs serve as useful molecular probes to explore the secondary binding site, which can be exploited in designing more potent DAAO inhibitors.

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