2. Academic Validation
  3. Rearranged limonoids and chromones from Harrisonia perforata and their anti-inflammatory activity

Rearranged limonoids and chromones from Harrisonia perforata and their anti-inflammatory activity

  • Bioorg Med Chem Lett. 2013 Jul 1;23(13):3896-900. doi: 10.1016/j.bmcl.2013.04.064.
Siwattra Choodej 1,  Damrong Sommit,  Khanitha Pudhom
Affiliations

Affiliation

  • 1 Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
PMID: 23688954 DOI: 10.1016/j.bmcl.2013.04.064
Abstract

Two new rearranged limonoids, harperforatin (1) and harperfolide (2), and a new chromone, harperamone (3), were isolated from fruits and roots of Harrisonia perforata, together with eight known compounds. Their structures were elucidated on the basis of spectroscopic data. Harperfolide (2) exhibited potent anti-inflammatory activity by suppressing nitric oxide (NO) production from activated macrophages with IC50 value of 6.51 μM. Furthermore, its effect is mediated by reduction of iNOS protein expression, attributable to the inhibitory action of LPS-induced NO production.

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