2. Academic Validation
  3. A secreted PTEN phosphatase that enters cells to alter signaling and survival

A secreted PTEN phosphatase that enters cells to alter signaling and survival

  • Science. 2013 Jul 26;341(6144):399-402. doi: 10.1126/science.1234907.
Benjamin D Hopkins 1,  Barry Fine,  Nicole Steinbach,  Meaghan Dendy,  Zachary Rapp,  Jacquelyn Shaw,  Kyrie Pappas,  Jennifer S Yu,  Cindy Hodakoski,  Sarah Mense,  Joshua Klein,  Sarah Pegno,  Maria-Luisa Sulis,  Hannah Goldstein,  Benjamin Amendolara,  Liang Lei,  Matthew Maurer,  Jeffrey Bruce,  Peter Canoll,  Hanina Hibshoosh,  Ramon Parsons
Affiliations

Affiliation

  • 1 Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029, USA.
PMID: 23744781 DOI: 10.1126/science.1234907
Abstract

Phosphatase and tensin homolog on chromosome ten (PTEN) is a tumor suppressor and an antagonist of the phosphoinositide-3 kinase (PI3K) pathway. We identified a 576-amino acid translational variant of PTEN, termed PTEN-Long, that arises from an alternative translation start site 519 base pairs upstream of the ATG initiation sequence, adding 173 N-terminal Amino acids to the normal PTEN open reading frame. PTEN-Long is a membrane-permeable lipid Phosphatase that is secreted from cells and can enter Other cells. As an exogenous agent, PTEN-Long antagonized PI3K signaling and induced tumor cell death in vitro and in vivo. By providing a means to restore a functional tumor-suppressor protein to tumor cells, PTEN-Long may have therapeutic uses.

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