2. Academic Validation
  3. Alstoniaphyllines A-C, unusual nitrogenous derivatives from the bark of Alstonia macrophylla

Alstoniaphyllines A-C, unusual nitrogenous derivatives from the bark of Alstonia macrophylla

  • J Nat Prod. 2013 Apr 26;76(4):723-6. doi: 10.1021/np3006937.
Sarot Cheenpracha 1,  Thunwadee Ritthiwigrom,  Surat Laphookhieo
Affiliations

Affiliation

  • 1 School of Science, University of Phayao, Maeka, Muang, Phayao 56000, Thailand. sarot.ch@up.ac.th
PMID: 23806072 DOI: 10.1021/np3006937
Abstract

Chemical investigation of an alkaloidal extract of Alstonia macrophylla bark led to the isolation and identification of two new nitrogenous derivatives, alstoniaphyllines A (1) and B (2), a new indole alkaloid, alstoniaphylline C (4), and eight known Alkaloids (3, 5-11). Alstonisine (9) exhibited antiplasmodial activity against Plasmodium falciparum, with an IC50 of 7.6 μM.

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