2. Academic Validation
  3. Caesalpins A-H, bioactive cassane-type diterpenes from the seeds of Caesalpinia minax

Caesalpins A-H, bioactive cassane-type diterpenes from the seeds of Caesalpinia minax

  • J Nat Prod. 2013 Jun 28;76(6):1025-31. doi: 10.1021/np300918q.
Guoxu Ma 1,  Jingquan Yuan,  Haifeng Wu,  Li Cao,  Xiaopo Zhang,  Lijia Xu,  Hua Wei,  Lizhen Wu,  Qingxia Zheng,  Liyong Li,  Lijing Zhang,  Junshan Yang,  Xudong Xu
Affiliations

Affiliation

  • 1 Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, People's Republic of China.
PMID: 23806110 DOI: 10.1021/np300918q
Abstract

Eight new cassane-type diterpenes, caesalpins A-H (1-8), were isolated from the ethyl acetate extract of Caesalpinia minax. Compound 1 displayed significant antiproliferative activity against HepG-2 (IC50 4.7 μM) and MCF-7 (IC50 2.1 μM) cells, and compounds 2 and 4 exhibited selective cytotoxic activities against MCF-7 (IC50 7.9 μM) and AGS (IC50 6.5 μM) cells.

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