2. Academic Validation
  3. Synthesis, antimicrobial and cytotoxic activities of some novel thiazole clubbed 1,3,4-oxadiazoles

Synthesis, antimicrobial and cytotoxic activities of some novel thiazole clubbed 1,3,4-oxadiazoles

  • Eur J Med Chem. 2013 Sep:67:54-9. doi: 10.1016/j.ejmech.2013.06.029.
N C Desai 1,  Nayan Bhatt,  Hardik Somani,  Amit Trivedi
Affiliations

Affiliation

  • 1 Division of Medicinal Chemistry, Department of Chemistry (DST-FIST Sponsored), Mahatma Gandhi Campus, Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar 364 002, India. Electronic address: dnisheeth@rediffmail.com.
PMID: 23835482 DOI: 10.1016/j.ejmech.2013.06.029
Abstract

A series of thiazole clubbed 1,3,4-oxadiazole derivatives (5a-l) have been synthesized and characterized by IR, (1)H NMR, (13)C NMR and mass spectral analysis. Synthesized compounds were evaluated for their antimicrobial and cytotoxic activities. The results indicated that, compounds 5c and 5i exhibited the most potent Antibacterial activity. Compound 5f was found to be the most potent Antifungal agent. The structure activity relationship revealed that the presence of electron withdrawing groups at para position of phenyl ring remarkably enhanced the Antibacterial activity of synthesized compounds. Further, the results of preliminary MTT cytotoxicity studies on HeLa cells suggested that potent antimicrobial activity of 5b, 5c, 5f, 5h and 5i is accompanied by low cytotoxicity.

Keywords

1,3,4-Oxadiazole; Antibacterial activity; Antifungal activity; Cytotoxicity; Thiazole; Thiazole clubbed 1,3,4-oxadiazoles.

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