2. Academic Validation
  3. Emetic activity of zacopride in ferrets and its antagonism by pharmacological agents

Emetic activity of zacopride in ferrets and its antagonism by pharmacological agents

  • Eur J Pharmacol. 1990 Jun 8;181(3):303-6. doi: 10.1016/0014-2999(90)90094-m.
L F Sancilio 1,  L M Pinkus,  C B Jackson,  H R Munson Jr
Affiliations

Affiliation

  • 1 Department of Pharmacology, A.H. Robins Research Laboratories, Richmond, VA 23261-6609.
PMID: 2384137 DOI: 10.1016/0014-2999(90)90094-m
Abstract

Zacopride administered orally was more emetic in fed than in fasted ferrets. The emetic activity of zacopride (0.1 mg/kg p.o.) was inhibited (100%) by 0.1 mg/kg i.p. of zacopride and 1 mg/kg i.p. of ICS 205-930. Haloperidol (3.16 mg/kg i.p.) and prochlorperazine (3.16 mg/kg i.p.) were weakly effective. N-acetyl-5-hydroxytryptophyl-5-hydroxytryptophan amide, a 5-HT1P antagonist, was inactive. Thus, the emetic activity of zacopride, like that of cisplatin, is blocked by 5-HT3 receptor antagonists.

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