2. Academic Validation
  3. Synthesis and cytotoxic activity evaluation of 2,3-thiazolidin-4-one derivatives on human breast cancer cell lines

Synthesis and cytotoxic activity evaluation of 2,3-thiazolidin-4-one derivatives on human breast cancer cell lines

  • Bioorg Med Chem Lett. 2013 Sep 1;23(17):4990-5. doi: 10.1016/j.bmcl.2013.06.051.
Marina Sala 1,  Adele Chimento,  Carmela Saturnino,  Isabel M Gomez-Monterrey,  Simona Musella,  Alessia Bertamino,  Ciro Milite,  Maria Stefania Sinicropi,  Anna Caruso,  Rosa Sirianni,  Paolo Tortorella,  Ettore Novellino,  Pietro Campiglia,  Vincenzo Pezzi
Affiliations

Affiliation

  • 1 Department of Pharmaceutical Science, Division of Biomedicine, University of Salerno, Fisciano, SA 84084, Italy.
PMID: 23860590 DOI: 10.1016/j.bmcl.2013.06.051
Abstract

It is well known that resveratrol (RSV) displayed cancer-preventing and Anticancer properties but its clinical application is limited because of a low bioavailability and a rapid clearance from the circulation. Aim of this work was to synthesize pharmacologically active resveratrol analogs with an enhanced structural rigidity and bioavailability. In particular, we have synthesized a library of 2,3-thiazolidin-4-one derivatives in which a thiazolidinone nucleus connects two aromatic rings. Some of these compounds showed strong inhibitory effects on breast Cancer cell growth. Our results indicate that some of thiazolidin-based resveratrol derivatives may become a new potent alternative tool for the treatment of human breast Cancer.

Keywords

2,3-Thiazolidin-4-one derivatives; Breast cancer cells; MCF-7; Polyphenol; Resveratrol analogs anticancer drugs; SKBR3.

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