2. Academic Validation
  3. First synthesis of a stable isotope of Ochratoxin A metabolite for a reliable detoxification monitoring

First synthesis of a stable isotope of Ochratoxin A metabolite for a reliable detoxification monitoring

  • Org Lett. 2013 Aug 2;15(15):3888-90. doi: 10.1021/ol401630t.
Anaïs Bouisseau 1,  Aurélie Roland,  Florence Reillon,  Rémi Schneider,  Florine Cavelier
Affiliations

Affiliation

  • 1 IBMM, UMR-CNRS-5247, Universités Montpellier I and II, Place Eugène Bataillon, 34095 Montpellier, Cedex 5, France.
PMID: 23883293 DOI: 10.1021/ol401630t
Abstract

Due to its toxicity and presence in numerous food products, Ochratoxin A (OTA) has drawn attention for decades. This article summarizes the first synthesis of a labeled analogue of Ochratoxin α (OTα), one of the main products generated by the metabolization of OTA by Microorganisms. This synthesis also led to a new labeled analogue of OTA with the deuteration located on the dihydroisocoumarin moiety allowing thus both the accurate quantification of OTA and OTα and the establishing of a reliable detoxification rate.

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