2. Academic Validation
  3. Synthesis of imine-pyrazolopyrimidinones and their mechanistic interventions on anticancer activity

Synthesis of imine-pyrazolopyrimidinones and their mechanistic interventions on anticancer activity

  • Bioorg Med Chem. 2013 Sep 15;21(18):5782-93. doi: 10.1016/j.bmc.2013.07.016.
Ashish T Baviskar 1,  Uttam C Banerjee,  Mukesh Gupta,  Rajveer Singh,  Sunil Kumar,  Manish K Gupta,  Sanjeev Kumar,  Satish K Raut,  Madhu Khullar,  Sandeep Singh,  Raj Kumar
Affiliations

Affiliation

  • 1 Department of Pharmaceutical Technology, National Institute of Pharmaceutical Education and Research, Mohali, S.A.S. Nagar, Punjab, India.
PMID: 23920485 DOI: 10.1016/j.bmc.2013.07.016
Abstract

Design, synthesis and Anticancer activity of a series of imine-pyrazolopyrimidinones is reported for the first time. Compounds 9d, 9n and 9o in the series show encouraging in vitro Anticancer activity with low micromolar IC50 values against prostate (PC3) and breast (MCF7) Cancer cell lines. Some notions about structure-activity relationships and plausible mechanism of biological activity are presented.

Keywords

Anticancer agents; Catalytic topoisomerase inhibitors; Effects on G2/M phase of the cell cycle; Imine-pyrazolopyrimidinones; Synthesis.

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