TMPRSS2 is an activating protease for respiratory parainfluenza viruses

J Virol. 2013 Nov;87(21):11930-5. doi: 10.1128/JVI.01490-13.

Masako Abe ¹, Maino Tahara, Kouji Sakai, Hiromi Yamaguchi, Kazuhiko Kanou, Kazuya Shirato, Miyuki Kawase, Masahiro Noda, Hirokazu Kimura, Shutoku Matsuyama, Hideo Fukuhara, Katsumi Mizuta, Katsumi Maenaka, Yasushi Ami, Mariko Esumi, Atsushi Kato, Makoto Takeda

Affiliations

Affiliation

1 Department of Virology 3.

PMID: 23966399 DOI: 10.1128/JVI.01490-13

Abstract

Here, we show that human parainfluenza viruses and Sendai virus (SeV), like Other respiratory viruses, use TMPRSS2 for their activation. The membrane fusion proteins of respiratory viruses often possess serine and glutamine residues at the P2 and P3 positions, respectively, but these residues were not critical for cleavage by TMPRSS2. However, mutations of these residues affected SeV growth in specific epithelial cell lines, suggesting the importance of these residues for SeV replication in epithelia.

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