2. Academic Validation
  3. New nemadectin congeners with acaricidal and nematocidal activity from Streptomyces microflavus neau3 Y-3

New nemadectin congeners with acaricidal and nematocidal activity from Streptomyces microflavus neau3 Y-3

  • Bioorg Med Chem Lett. 2013 Oct 15;23(20):5710-3. doi: 10.1016/j.bmcl.2013.08.002.
Ling-Yu Yang 1,  Ji-Dong Wang,  Ji Zhang,  Chang-Yan Xue,  Hui Zhang,  Xiang-Jing Wang,  Wen-Sheng Xiang
Affiliations

Affiliation

  • 1 School of Life Science, Northeast Agricultural University, No. 59, Mucai Street, Xiangfang District, Harbin 150030, PR China.
PMID: 23992860 DOI: 10.1016/j.bmcl.2013.08.002
Abstract

Two nemadectin congeners 1 and 2 were isolated from the fermentation broth of a mutant strain (Y-3) of Streptomyces microflavus neau3. Their structures were determined on the basis of extensive spectroscopic analysis and comparison with data from the literature. Compound 2 possessed a 5-membered ring lactone that is unprecedented among known milbemycins and avermectins. Both compounds 1 and 2 exhibited potent acaricidal activity and nematocidal activity. Especially, compound 2 demonstrated impressive acaricidal activity against adult mites with an IC50 of 2.3±0.9 μg/mL and Mite eggs with an IC50 of 17.5±2.1 μg/mL and nematocidal activity against Caenorhabditis elegans with an IC50 of 0.7±0.2 μg/mL, which are higher than those of nemadectin and the known commercial acaricide and nematocide milbemycin A3/A4.

Keywords

Acaricidal activity; Nemadectin congeners; Nematocidal activity; Streptomyces microflavus neau3.

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