2. Academic Validation
  3. The cytotoxicity of 8-O-4' neolignans from the seeds of Crataegus pinnatifida

The cytotoxicity of 8-O-4' neolignans from the seeds of Crataegus pinnatifida

  • Bioorg Med Chem Lett. 2013 Oct 15;23(20):5599-604. doi: 10.1016/j.bmcl.2013.08.045.
Xiao-Xiao Huang 1,  Chen-Chen Zhou,  Ling-Zhi Li,  Fei-Fei Li,  Li-Li Lou,  Dian-Ming Li,  Takshi Ikejima,  Ying Peng,  Shao-Jiang Song
Affiliations

Affiliation

  • 1 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Rd., Shenyang 110016, PR China; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, PR China.
PMID: 23999046 DOI: 10.1016/j.bmcl.2013.08.045
Abstract

Nine new 8-O-4' neolignans, named pinnatifidanin B I-IX (1-9), together with 9 known analogs (10-18) were isolated from the seeds of Crataegus pinnatifida. The structures of 1-18 were determined by spectroscopic methods, including 1D, 2D NMR, CD and HRESIMS analysis. Compounds 8-11, 17 and 18 displayed potent cytotoxic activities against human Cancer cell lines, and most interestingly, none of the 6 compounds displayed inhibitory activity against human lung cell line (Mrc5). The 6 cytotoxic compounds are considered to be potential as antitumor agents, which could significantly inhibit the Cancer cell growth in a dose-dependent manner and are probably safer than positive control drug.

Keywords

8-O-4′ Neolignans; Crataegus pinnatifida; Cytotoxicities.

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