Anti-inflammatory constituents from the fruits of Vitex rotundifolia

Bioorg Med Chem Lett. 2013 Nov 1;23(21):6010-4. doi: 10.1016/j.bmcl.2013.08.004.

Chul Lee ¹, Jin Woo Lee, Qinghao Jin, Hak Ju Lee, Sung-Joon Lee, Dongho Lee, Myung Koo Lee, Chong Kil Lee, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang

Affiliations

Affiliation

1 College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea.

PMID: 24035341 DOI: 10.1016/j.bmcl.2013.08.004

Abstract

Three new diterpenes (7, 15 and 17) and two new neolignans (19 and 20) along with nineteen known compounds have been isolated from the fruits of Vitex rotundifolia. Their structures were elucidated by a combination of 1D and 2D NMR, HRESI-MS, and CD data. All isolates were tested for their inhibitory activities on LPS-induced nitric oxide production in RAW264.7 cells. Of these, compounds 3, 4, 7, 13, 15, 19, and 24 found to inhibit nitric oxide production with the IC50 values ranging from 11.3 to 24.5μM.

Keywords

Diterpene; Neolignan; Nitric oxide; Verbenaceae; Vitex rotundifolia.

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