2. Academic Validation
  3. Phomapyrrolidones A-C, antitubercular alkaloids from the endophytic fungus Phoma sp. NRRL 46751

Phomapyrrolidones A-C, antitubercular alkaloids from the endophytic fungus Phoma sp. NRRL 46751

  • J Nat Prod. 2013 Oct 25;76(10):1860-5. doi: 10.1021/np400391p.
E M Kithsiri Wijeratne 1,  Hongping He,  Scott G Franzblau,  Angela M Hoffman,  A A Leslie Gunatilaka
Affiliations

Affiliation

  • 1 Southwest Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, The University of Arizona , 250 E. Valencia Road, Tucson, Arizona 85706, United States.
PMID: 24079882 DOI: 10.1021/np400391p
Abstract

Three new Alkaloids, phomapyrrolidones A-C (1-3), bearing a cyclopenta[b]fluorene ring system were isolated from the mycelium extract of the endophytic Fungal strain Phoma sp. NRRL 46751, inhabiting Saurauia scaberrinae. Methylation of 1 afforded its N-methyl derivative 4. The planar structures and relative configurations of 1-4 were elucidated by extensive spectroscopic analysis. Phomapyrrolidones B (2) and C (3) exhibited weak antitubercular activity at subcytotoxic concentrations.

Figures