2. Academic Validation
  3. Withanolide-based steroids from the cultured soft coral Sinularia brassica

Withanolide-based steroids from the cultured soft coral Sinularia brassica

  • J Nat Prod. 2013 Oct 25;76(10):1902-8. doi: 10.1021/np400454q.
Chiung-Yao Huang 1,  Chih-Chuang Liaw,  Bo-Wei Chen,  Pei-Chin Chen,  Jui-Hsin Su,  Ping-Jyun Sung,  Chang-Feng Dai,  Michael Y Chiang,  Jyh-Horng Sheu
Affiliations

Affiliation

  • 1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University , Kaohsiung 804, Taiwan.
PMID: 24128077 DOI: 10.1021/np400454q
Abstract

Seven novel withanolides, sinubrasolides A-G (1-7), have been isolated from the cultured soft coral Sinularia brassica. The structures of the new metabolites were determined by extensive spectroscopic analyses, and the absolute configuration of 1 was established by X-ray crystallographic analysis. The cytotoxicities of compounds 1-7 against a limited panel of Cancer cell lines also were determined.

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