2. Academic Validation
  3. Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus

Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus

  • Bioorg Med Chem Lett. 2014 Jan 1;24(1):367-70. doi: 10.1016/j.bmcl.2013.10.072.
Kim-Hung Lam 1,  Roberto Gambari 2,  Kenneth Ka-Ho Lee 3,  Yi-Xin Chen 4,  Stanton Hon-Lung Kok 3,  Raymond Siu-Ming Wong 3,  Fung-Yi Lau 3,  Chor-Hing Cheng 5,  Wai-Yeung Wong 6,  Zhao-Xiang Bian 7,  Albert Sun-Chi Chan 8,  Johnny Cheuk-On Tang 9,  Chung-Hin Chui 10
Affiliations

Affiliations

  • 1 State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China. Electronic address: kim.hung.lam@polyu.edu.hk.
  • 2 Centre of Biotechnology, Department of Life Sciences and Biotechnology, The University of Ferrara, Ferrara, Italy.
  • 3 School of Biomedical Sciences and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
  • 4 Department of Chemistry, Guangzhou University, Guangzhou, People's Republic of China.
  • 5 State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China.
  • 6 Institute of Creativity, Department of Chemistry and Institute of Advanced Materials, Hong Kong Baptist University, Waterloo Road, Kowloon Tong, Hong Kong, China.
  • 7 Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Waterloo Road, Kowloon Tong, Hong Kong, China.
  • 8 Institute of Creativity, Department of Chemistry and Institute of Advanced Materials, Hong Kong Baptist University, Waterloo Road, Kowloon Tong, Hong Kong, China; Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Waterloo Road, Kowloon Tong, Hong Kong, China.
  • 9 State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China. Electronic address: dr-johnny.tang@polyu.edu.hk.
  • 10 State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China; School of Biomedical Sciences and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China; Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Waterloo Road, Kowloon Tong, Hong Kong, China. Electronic address: chchui@graduate.hku.hk.
PMID: 24269165 DOI: 10.1016/j.bmcl.2013.10.072
Abstract

This work describes the preparation of quinoline compounds as possible anti-bacterial agents. The synthesized quinoline derivatives show anti-bacterial activity towards Staphylococcus aureus. It is interesting to observe that the synthetic 5,7-dibromo-2-methylquinolin-8-ol (4) shows a similar minimum inhibitory concentration of 6.25μg/mL as compared to that of methicillin (3.125μg/mL) against Staphylococcus aureus.

Keywords

Antibacterial agents; Antibiotics; Quinolines; Staphylococcus aureus.

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