Cytotoxic activity of gypenosides and gynogenin against non-small cell lung carcinoma A549 cells

Bioorg Med Chem Lett. 2014 Jan 1;24(1):186-91. doi: 10.1016/j.bmcl.2013.11.043.

Dao-Jin Chen ¹, Hui-Min Liu ¹, Shao-Fang Xing ¹, Xiang-Lan Piao ²

Affiliations

1 Institute of Chinese Minority Traditional Medicine, Minzu University of China, Beijing 100081, China.
2 Institute of Chinese Minority Traditional Medicine, Minzu University of China, Beijing 100081, China. Electronic address: xlpiao@163.com.

PMID: 24321343 DOI: 10.1016/j.bmcl.2013.11.043

Abstract

The activity of gypenosides and gynogenin of Gynostemma pentaphyllum against non-small cell lung carcinoma (NSCLC) A549 cells was investigated to identify the structural characteristics of gypenosides and gynogenin to have anti-NSCLC activity. Of the tested dammarane-type compounds, 20S-dammar-24-en-2α,3β,12β,20-tetrol showed the strongest activity against A549 cells. Based on the structure and cytotoxic activity relationships of gypenosides and gynogenin, the OH group in C-2, the connected sugar number and the configuration in C-20 were important for cytotoxic activity against A549 cells.

Keywords

A549 cell; Gynogenin; Gypenoside; Non-small cell lung carcinoma (NSCLC); Saponins conversion.

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