2. Academic Validation
  3. Napyradiomycin derivatives, produced by a marine-derived actinomycete, illustrate cytotoxicity by induction of apoptosis

Napyradiomycin derivatives, produced by a marine-derived actinomycete, illustrate cytotoxicity by induction of apoptosis

  • J Nat Prod. 2014 Jan 24;77(1):15-21. doi: 10.1021/np400466j.
Lauge Farnaes 1,  Nicole G Coufal,  Christopher A Kauffman,  Arnold L Rheingold,  Antonio G DiPasquale,  Paul R Jensen,  William Fenical
Affiliations

Affiliation

  • 1 Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego , La Jolla, California 92093-0204, United States.
PMID: 24328269 DOI: 10.1021/np400466j
Abstract

The microbial production, isolation, and structure elucidation of four new napyradiomycin congeners (1-4) is reported. The structures of these compounds, which are new additions to the marine-derived meroterpenoids, were defined by comprehensive spectroscopic analysis and by X-ray crystallography. Using fluorescence-activated cell sorting (FACS) analysis, napyradiomycins 1-4 were observed to induce Apoptosis in the colon adenocarcinoma cell line HCT-116, indicating the possibility of a specific biochemical target for this class of cytotoxins.

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