2. Academic Validation
  3. Thiodiketopiperazines from the marine-derived fungus Phoma sp. OUCMDZ-1847

Thiodiketopiperazines from the marine-derived fungus Phoma sp. OUCMDZ-1847

  • J Nat Prod. 2014 Jan 24;77(1):132-7. doi: 10.1021/np400802d.
Fandong Kong 1,  Yi Wang,  Peipei Liu,  Tianhan Dong,  Weiming Zhu
Affiliations

Affiliation

  • 1 Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, People's Republic of China.
PMID: 24370114 DOI: 10.1021/np400802d
Abstract

Three new thiodiketopiperazines, named phomazines A-C (1-3), along with 10 known analogues (4-13), were isolated from the fermentation broth of an endophytic fungus, Phoma sp. OUCMDZ-1847, associated with the mangrove plant Kandelia candel. The structures including the absolute configurations of the new compounds were unambiguously elucidated by spectroscopic, X-ray crystallographic, and Mosher's methods along with quantum ECD and (13)C NMR calculations. Compounds 2, 4, 5, 11, and 12 showed cytotoxicities against the HL-60, HCT-116, K562, MGC-803, and A549 cell lines with IC50 values in the range 0.05 to 8.5 μM.

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