Bifunctional thiosialosides inhibit influenza virus

Bioorg Med Chem Lett. 2014 Jan 15;24(2):636-43. doi: 10.1016/j.bmcl.2013.11.077.

Yang Yang ¹, Yun He ¹, Xingzhe Li ¹, Hieu Dinh ¹, Suri S Iyer ²

Affiliations

1 788 Petit Science Center, Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302, United States.
2 788 Petit Science Center, Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302, United States. Electronic address: siyer@gsu.edu.

PMID: 24374271 DOI: 10.1016/j.bmcl.2013.11.077

Abstract

We have synthesized a panel of bivalent S-sialoside analogues, with modifications at the 4 position, as inhibitors of Influenza Virus. These first generation compounds show IC50 values ranging from low micromolar to high nanomolar in Enzyme inhibition and plaque reduction assays with two intact viruses, Influenza H1N1 (A/California/07/2009) and H3N2 (A/Hongkong/8/68).

Keywords

Bifunctional; Glycoconjugates; Influenza virus; Inhibitors; Sialic acid.

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